MMPS — MATRIX METALO PROTEINASES
Most important proteinase involved in destruction of
periodontal tissue
EG: MMP – 8, MMP – 13


GINGIVAL CREVICULAR FLUID

 GCF has most abundance of IgG
 CONTAINS
o Components of CT
o Epithelium
o Inflammatory cells
o Serum
o Microbial flora living there in the sulcus
 More neutrophils to defend the gingiva.
 Most drug concentration
o 1st tetracycline/doxycycline
o 2nd metronidazole
 DOXYCYCLINE – similar to tetracycline

QN Tetracycline cause brownish discoloration in all teeth & appear yellowish with UV light

 Pedo —20mg
 Therapeutic value — 100mg /day (Antibacterial dose)
 Sub antimicrobial dose = 20mg — bacteriostatic at GCF