It is odd how people don't wonder.
https://www.geni.com/projects/Signers-of-the-Declaration-of-Independence-on-4-July-1776/10
Descent
Only 15 of the 56 signers have male descendants today.

These Signers have no descendants: William Whipple, John Hancock, Samuel Huntington, James Smith, James Wilson, Caesar Rodney, George Wythe, Francis Lightfoot Lee, Joseph Hewes, Thomas Lynch, Jr. Button Gwinnett, Lyman Hall, and George Walton.

These Signers have no same surname (male) descendants: Josiah Bartlett, Matthew Thornton, Samuel Adams, Elbridge Gerry, William Williams, William Floyd, Francis Lewis, Robert Morris, Benjamin Rush, Benjamin Franklin, George Clymer, George Taylor, George Ross, Thomas McKean, Samuel Chase, Thomas Stone, Thomas Jefferson, William Hooper and John Penn.