Dr. Susan and Dr. Jolle, famous cat veterinarians, discuss hybrid cats. What are hybrid cats, how do you make them, and what are the benefits and disadvantages? A hybrid cat is the result of breeding two different cat breeds (often a wild breed) to combine certain desirable traits from each breed. These hybrids can occur naturally or through intentional breeding. For example, the Bengal cat is a popular hybrid breed, resulting from crossing domestic cats with Asian leopard cats. Hybrid cats can exhibit a mix of physical characteristics and temperaments from both parent breeds, creating unique and sometimes sought-after traits in the resulting offspring.