How to Kill a Piano is a fictional coming-of-age black comedy-drama story. It incorporates elements of dark humor and existentialist drama. The plot revolves around the exploits of a young young man named George who is adopted into a home by a man he calls Uncle Charlie. Charlie teaches George about living life to its fullest and that life is the most precious gift of all. A demonic piano threatens the very fabric of that life and George must safe Charlie and the world from an unavoidable tragic doom.

A baby grand piano, dating over one hundred years, is delivered by the devil's henchmen to the basement of Charlie Seraphic's home. Charlie becomes possessed by the instrumental beast and an orphan, George, seems to be the only one who might be able to save him from the evil musical force dwelling below the floorboards.