The only Vice President to resign the office voluntarily is a much more interesting character than just that fact.  From a local politico to second-highest office in the land in five years, Agnew took an important role as Nixon's Nixon, attacking the news media and the so called hippie culture of the sixties.  Opponents pushed back, and he doubled down.  But his resignation was due to his own actions, and to some degree, the President he served.