In this episode of 'BeeWellwithMS', Dr. Agne Straukiene MS Neurologist is joined by Professor Jeremy Hobart for a discussion on advancements in measuring health outcomes for multiple sclerosis (MS). Professor Hobart, a renowned clinician and advisor, elaborates on the evolution of measurement tools, their impact on current practices, and the increasing focus on patient-centered outcomes. The conversation highlights the extended history of instruments like the Expanded Disability Status Scale (EDSS) and the need for innovations to enhance personalised medicine. They discuss the limitations of these historical tools, ethical considerations in MS research, and the importance of structured and sensitive measurement processes. Despite challenges, there are promising developments in utilising real-time data and patient-based assessments to improve clinical outcomes and treatment efficacy in MS, emphasising a call for coordinated global efforts and advancements in clinical trial designs.